I would expect a single to work better with the more extreme versions of the hulls where the widepoint and riding position are so far forward and the tail rockers are super low. And for sure, you'd do a bottom a little differently if you meant to leverage and turn a board off the fin(s). My theory (don't know the answer) is that if a more moderately rockered/foiled Vaquero was actually shaped for a 2+1 cluster then that bottom and tail might work with a Webber style twin.Anything will work. Depending on how open your mind is, it may or may not be fun for you.
That being said, a hull’s engine is the interplay between the rail and a single, tuned fin. The convex bottom facilitates that relationship, rolling and winding-up as you shift through the various gears.
With hulls, I find that any additional fins placed closer to the rail only serve a less efficient means of directional stability. At that point I’d be more inclined to surf a thruster or fish.
All that aside, this is just spitballing about trying a different fin combo than the board was designed to use. If it was a serious discussion about a midlength running twins then it would only make sense to design the board to be trimmed, ridden and turned off a twin setup, not 2ft further forward. Wide point back like a Fowler Platypus or a a Robin Mair Quadmatic or a Lovelace v.bowls, except using a twin-friendly bottom.