Malaria drug mentioned by Trump "cured" this guy

manbearpig

Duke status
May 11, 2009
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in the bathroom
My gut told me at the time typical dose was around 500mg but I didn't say so at the time cause it's not something I'm very familiar with. Turns out it's 400mg.

Anyhow, you're still ignoring the fact the dosages you linked to were self-inflicted overdoses far beyond the prescribed doses. You didn't provide any context acknowledging this.

The context should have been...."Yes, it's very deadly in the hands of toddlers and idiots."

That is all.
so now they were self inflicted? But two posts ago it was accidental!

there are varying dosages, some not far from the dosages I provided examples of or within that range. I am shocked you didn’t provide the context to acknowledge this!

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kidfury

Duke status
Oct 14, 2017
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ED vs LD is pretty close. How many drugs are lethal at 4X the effective dose?


  1. Toxic dose. The therapeutic dose of chloroquine phosphate is 500 mg once a week for malaria prophylaxis or 2.5 g over 2 days for treatment of malaria. Deaths have been reported in children after ingesting one or two tablets—doses as low as 300 mg; the lethal dose of chloroquine for an adult is estimated at 30–50 mg/kg.
 

hammies

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Apr 8, 2006
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People are fucking morons. Cheeto says Chloroquine is a Covid cure so they go to aquarium supply stores where they sell chloroquine phosphate and self-medicate themselves straight to the ER (or morgue)
 

Mike_Jones

Tom Curren status
Mar 5, 2009
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Hydrochloroquine has been tested and proven safe by the FDA. Today Trump announced that something like 2,000 doses of hydrochloroquine will be available for testing at New York hospitals.

CHLOROQUINE: THE STRANGE STORY BEHIND THE "CURE" FOR COVID-19 THAT'S GOING VIRAL

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.....Rigano was reluctant to take full credit for the findings touted in the document.

"I need to let [Raoult] have his day here," Rigano tells Inverse. "It’s the first well-controlled study showing that hydroxy chloroquine and azithryomycin are cures to coronavirus."

"Him and his team are saving us," Rigano says.

Raoult is reported as the lead author of a study that claims to be published in the International Journal of Antimicrobial Agents as of Tuesday, March 17. As of the time of writing, the cited link to the study returns no results, but Raoult's institution has released a manuscript of the paper on their website.

Hartmut Derendorf, a professor emeritus of pharmaceutics at the University of Floria is an editor of The International Journal of Antimicrobial Agents. He confirmed to Inverse that the study has been peer-reviewed and submitted to that journal:

"The paper will be published shortly and is currently being processed," Derendorf says.....
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Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an openlabel non-randomized clinical trial

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Abstract

Background
Chloroquine and hydroxychloroquine have been found to be efficient on SARS-CoV-2, and
reported to be efficient in Chinese COV-19 patients. We evaluate the role of
hydroxychloroquine on respiratory viral loads.

Patients and methods
French Confirmed COVID-19 patients were included in a single arm protocol from early
March to March 16th, to receive 600mg of hydroxychloroquine daily and their viral load in
nasopharyngeal swabs was tested daily in a hospital setting. Depending on their clinical
presentation, azithromycin was added to the treatment. Untreated patients from another center
and cases refusing the protocol were included as negative controls. Presence and absence of
virus at Day6-post inclusion was considered the end point.
Results

Six patients were asymptomatic, 22 had upper respiratory tract infection symptoms and eight
had lower respiratory tract infection symptoms.
Twenty cases were treated in this study and showed a significant reduction of the viral
carriage at D6-post inclusion compared to controls, and much lower average carrying duration
than reported of untreated patients in the literature. Azithromycin added to
hydroxychloroquine was significantly more efficient for virus elimination.

Conclusion
Despite its small sample size our survey shows that hydroxychloroquine treatment is
significantly associated with viral load reduction/disappearance in COVID-19 patients and its
effect is reinforced by azithromycin.
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If I didn't know the left like the back of my hand I would be gobsmacked that anyone would root for this to fail and for thousands of people to fall ill and die
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kidfury

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Oct 14, 2017
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Don’t be a dick. 20 treated and 16 not treated is likely to be an adequate sample size. The problem is lack of randomization.
 

Mike_Jones

Tom Curren status
Mar 5, 2009
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20 treated and 16 not treated is likely to be an adequate sample size.

.....FOR EFFICACY.

For Safety? We already know that. Hydrochloroquinalone is safe. Period.

For efficacy? Randomization is a necessity for testing efficacy in normal-sized test groups. More data points provides what randomization provides in smaller studies. You will have the answers you are demanding in relatively short order without anyone being harmed.
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kidfury

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Oct 14, 2017
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Im only demanding that you tell us what your diagnoses have been. (Kidding. Don’t tell us).
 

Mike_Jones

Tom Curren status
Mar 5, 2009
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Something like 20 years ago the FDA overhauled its drug approval process for cancer patients. Hospitals had new experimental drugs, but were forced to withhold them from study control group patients while watching them die. The revised rules said oncologists can test drugs on terminally ill patients without feeding placebos to control group participants. Trump further changed the rules to allow experimental cancer treatments which have only been tested safe, not effective, to terminally ill patients. Trump overruled the previous FDA reasoning which said that we can't feed experimental drugs to terminally ill patients because it could kill them.

It's high time we spread these pragmatic drug approval principles to other types of drugs. Hydrochloroquine is a start.
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Surfdog

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Apr 22, 2001
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I've heard/read more stories about the couple people dying of idiotic ingesting chloroquine phosphate, than the potential for Hydrochloroquine to help a lot with CV-19's worst effects.

Keep your doctor? Save $2500 on premium?
 

Mike_Jones

Tom Curren status
Mar 5, 2009
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The next drug treatment this principle should be applied to is naltrexone, the time-release form of naloxone. People know naloxone as Narcan. The FDA approves use of naltrexone for treating opioid overdose. However, hundreds of people across America are using low doses of naltrexone for treating various autoimmune diseases. Ongoing high doses of naltrexone present health risks, but long-term use of low doses have been shown to be safe. The treatment is known as low-dose naltrexone (LDN).

Prescribing off-label use of LDN subjects doctors to career-ending criminal prosecution. The obstacle standing in the way of FDA testing and approving LDN comes from the chemical pathways which LDN exposes. The fact that LDN works against opioids and against autoimmune disease says that people must be ingesting harmful opioids regularly. And that's exactly what they are doing.

Besides drugs the FDA is responsible for approving foods, and LDN approval says that some of the FDA's approved foods are harming some people. Besides this, medical operators and doctors have erected a huge multi-million dollar industry around the approved medical treatment of autoimmune disease. FDA approval of LDN for autoimmune disease threatens this industry as well as the careers of the practicing physicians.
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GromsDad

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Jan 21, 2014
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West of the Atlantic. East of the ICW.
It's not a cure, but it's something that may be a lifesaving treatment.

The fact people are essentially rooting against it is bizarre.

After Trump mentioned it there was a proliferation of internet DEADLY 2G DOSE! fearmongering about the drug.
Just like when statistics started to show that it was mostly old people who were dying. The media went on a full court press to find a young person who had died. They breathlessly reported when they found one such individual. As it turned out that guy was being treated for Leukemia and was particularly susceptible to any virus or infection.
 

afoaf

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Jun 25, 2008
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I love it when squidley plays make-believe doctor, or make-believe
economist, or make-believe nutritionist, or make-believe human being
 
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Mike_Jones

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Mar 5, 2009
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Just like when statistics started to show that it was mostly old people who were dying. The media went on a full court press to find a young person who had died. They breathlessly reported when they found one such individual. As it turned out that guy was being treated for Leukemia and was particularly susceptible to any virus or infection.

Diseases are age-related, not age dependent. The older the person, the sicker the person. That doesn't mean younger people can't be sick.
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