FDA just lost a historic ivermectin lawsuit

StuAzole

Duke status
Jan 22, 2016
29,570
10,608
113
Remember when we were told that breakthrough infections were incredibly rare, and that you would never die of Covid if you were vaccinated :unsure: And remember how the people who told us that were accused of spreading misinformation?

Weird
There’s another thread about this, or did you forget.

im only here bc squidley’s initial link was so ridiculous.
 

kidfury

Duke status
Oct 14, 2017
25,144
10,847
113

now do paxlovid
 

StuAzole

Duke status
Jan 22, 2016
29,570
10,608
113

now do paxlovid
Didn’t do sh!t for me recently.
 

afoaf

Duke status
Jun 25, 2008
49,990
23,691
113
my friend's mom came to visit and got the vid on the plane

wrecked her. doctor prescribed paxlovid.

seems better after a couple days.
 

Mike_Jones

Tom Curren status
Mar 5, 2009
11,695
2,438
113

now do paxlovid

.....also known as Pfizermectin. They're that close.

Paxlovid works, and it's not a spike protein derivative. Paxlovid is an antiviral, and works in one of the three ways which ivermectin works.
.
 
  • Haha
Reactions: kidfury

StuAzole

Duke status
Jan 22, 2016
29,570
10,608
113
.....also known as Pfizermectin. They're that close.

Paxlovid works, and it's not a spike protein derivative. Paxlovid is an antiviral, and works in one of the three ways which ivermectin works.
.
There should be some studies by now.

Link?
 

afoaf

Duke status
Jun 25, 2008
49,990
23,691
113
.....also known as Pfizermectin. They're that close.

Paxlovid works, and it's not a spike protein derivative. Paxlovid is an antiviral, and works in one of the three ways which ivermectin works.
.
and yet ivermectin has repeatedly been proven to be ineffective against covid

keep trying to make it happen, squidtard!
 
  • Like
Reactions: kidfury

Mike_Jones

Tom Curren status
Mar 5, 2009
11,695
2,438
113
and yet ivermectin has repeatedly been proven to be ineffective against covid

keep trying to make it happen, squidtard!

I can make any drug appear to fail .....especially a cheap drug which competes with a drug which I own stock in.

How Ivermectin Trials Were Designed to Fail

------------------------------------------
Despite the proven efficacy of ivermectin in treating COVID-19, some studies in top-tier journals have concluded otherwise. Which data should we trust?

.....Improper Dosing
.....
Clinical Improvement Despite Underdosing
.....Surprisingly, the source PDF was removed from the website during the writing of this article.
.....
Statistical Failures
In a randomized, double-blind, placebo-controlled clinical trial with mild to moderate COVID-19 patients, none of the 55 patients in the ivermectin group died, whereas four of 57 in the placebo group died. This resulted in a comparison of zero percent versus 7 percent. Moreover, only 1.8 percent of ivermectin-treated patients needed invasive ventilation compared to 8.8 percent in the placebo group.

In other words, ivermectin reduced the risk of death by 100 percent and the need for ventilators by 80 percent.

However, the article did not provide the p-value (probability value) for the death rate comparison or the invasive ventilation of 0.102 (Table 2), which is higher than the 0.05 threshold considered to be a significant statistical difference.
.....
Selection Bias
It’s common knowledge that early treatment of COVID-19 is crucial for effective results. The earlier the treatment starts, the more effective it is. These approved antivirals for COVID-19 are used shortly after COVID-19 infection and usually within a few days after symptom onset.

For example, Paxlovid and molnupiravir registration trials treated patients within only three to five days of symptom onset.

However, in the PRINCIPLE trial, ivermectin was used for patients within 14 days of symptom onset, while ACTIV-6 treated patients an average of six days after infection.

Patients with severe kidney disease are normally excluded from phase 3 studies, as they are less likely to respond to antiviral treatment. This approach has been taken by remdesivir (protocol), molnupiravir (protocol), and Paxlovid (protocol). However, such standard exclusion criteria were not taken by the ACTIV-6 or PRINCIPLE study protocols.
Why was ivermectin treated so unfairly in these clinical trials?

It is well known that when an RCT is sponsored by Big Pharma, there is often a financial conflict of interest, as the research institutions are usually hired or funded by the pharmaceutical company. In a world where wealth often competes with ethics, how many can resist financial temptation and stay true to moral principles?

“Hidden agenda bias” occurs when a trial is conducted to demonstrate a desired outcome, rather than to answer a question. In other words, “Don’t do a trial if it won’t show you what you want to find.”....
------------------------------------------
.
 
  • Haha
Reactions: afoaf

StuAzole

Duke status
Jan 22, 2016
29,570
10,608
113
I can make any drug appear to fail .....especially a cheap drug which competes with a drug which I own stock in.

How Ivermectin Trials Were Designed to Fail

------------------------------------------
Despite the proven efficacy of ivermectin in treating COVID-19, some studies in top-tier journals have concluded otherwise. Which data should we trust?

.....Improper Dosing
.....
Clinical Improvement Despite Underdosing
.....Surprisingly, the source PDF was removed from the website during the writing of this article.
.....
Statistical Failures
In a randomized, double-blind, placebo-controlled clinical trial with mild to moderate COVID-19 patients, none of the 55 patients in the ivermectin group died, whereas four of 57 in the placebo group died. This resulted in a comparison of zero percent versus 7 percent. Moreover, only 1.8 percent of ivermectin-treated patients needed invasive ventilation compared to 8.8 percent in the placebo group.

In other words, ivermectin reduced the risk of death by 100 percent and the need for ventilators by 80 percent.

However, the article did not provide the p-value (probability value) for the death rate comparison or the invasive ventilation of 0.102 (Table 2), which is higher than the 0.05 threshold considered to be a significant statistical difference.
.....
Selection Bias
It’s common knowledge that early treatment of COVID-19 is crucial for effective results. The earlier the treatment starts, the more effective it is. These approved antivirals for COVID-19 are used shortly after COVID-19 infection and usually within a few days after symptom onset.

For example, Paxlovid and molnupiravir registration trials treated patients within only three to five days of symptom onset.

However, in the PRINCIPLE trial, ivermectin was used for patients within 14 days of symptom onset, while ACTIV-6 treated patients an average of six days after infection.

Patients with severe kidney disease are normally excluded from phase 3 studies, as they are less likely to respond to antiviral treatment. This approach has been taken by remdesivir (protocol), molnupiravir (protocol), and Paxlovid (protocol). However, such standard exclusion criteria were not taken by the ACTIV-6 or PRINCIPLE study protocols.
Why was ivermectin treated so unfairly in these clinical trials?

It is well known that when an RCT is sponsored by Big Pharma, there is often a financial conflict of interest, as the research institutions are usually hired or funded by the pharmaceutical company. In a world where wealth often competes with ethics, how many can resist financial temptation and stay true to moral principles?

“Hidden agenda bias” occurs when a trial is conducted to demonstrate a desired outcome, rather than to answer a question. In other words, “Don’t do a trial if it won’t show you what you want to find.”....
------------------------------------------
.
Weird that trials only happen in America. No other place in the world is able to study the effectiveness of ivermectinI I guess.

Would China not use ivermectin if it worked?

Does India have a vested interest in protecting the big biotech firms? Pakistan? Russia? South Africa?
 

grapedrink

Duke status
May 21, 2011
26,534
15,453
113
A Beach
Weird that trials only happen in America. No other place in the world is able to study the effectiveness of ivermectinI I guess.

Would China not use ivermectin if it worked?

Does India have a vested interest in protecting the big biotech firms? Pakistan? Russia? South Africa?
All countries where corruption is non-existent.